(19)

(11)

EP 1 549 951 A2

(12)

(88) Date of publication A3: 19.02.2004 (43) Date of publication: 06.07.2005 Bulletin 2005/27 (21) Application number: 03739026.7 (22) Date of filing: 30.05.2003

(51) International Patent Classification (IPC)7: G01N 33/53, C12Q 1/68 (86) International application number: PCT/US2003/017412 (87) International publication number: WO 2003/102584 (11.12.2003 Gazette 2003/50)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR Designated Extension States: AL LT LV MK (30) Priority: 30.05.2002 US 384798 P 09.08.2002 US 402407 P 28.01.2003 US 443062 P 31.03.2003 US 403676 (71) Applicant: Curagen Corporation New Haven, CT 06511 (US)

(72) Inventors: ALVAREZ, Enrique Clinton, CT 06413 (US) ANDERSON, David, W. Branford, CT 06405 (US) DHANABAL, Mohanraj Branford, CT 06405 (US) KHRAMTSOV, Nikolai, V. Branford, CT 06405 (US) LAROCHELLE, William, J. Madison, CT 06443 (US) LICHENSTEIN, Henri, S. Guilford, CT 06437 (US) LI,Li Branford, CT 06405 (US) OOI, Chean, Eng Branford, CT 06405 (US) PADIGARU, Muralidhara Branford, CT 06405 (US) SHIMKETS, Richard, A. Guilford, CT 06437 (US) ZHONG, Mei Branford, CT 06405 (US) (74) Representative: Wales, Alice Irene  Mintz Levin,The Rectory,9 Ironmonger Lane London EC2V 8EY London EC2V 8EY (GB)