(19)
(11) EP 1 551 381 A2

(12)

(88) Date of publication A3:
17.06.2004

(43) Date of publication:
13.07.2005 Bulletin 2005/28

(21) Application number: 03757609.7

(22) Date of filing: 10.10.2003
(51) International Patent Classification (IPC)7A61K 31/165, A61K 31/216, A61K 31/137, A61K 31/277, A61K 31/662, A61P 35/00, A61P 35/02, A61P 37/06, A61P 31/22, A61P 27/02, A61P 19/08, A61P 17/00
(86) International application number:
PCT/CA2003/001558
(87) International publication number:
WO 2004/032911 (22.04.2004 Gazette 2004/17)
(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR
Designated Extension States:
AL LT LV MK

(30) Priority: 11.10.2002 US 417642 P
11.10.2002 CA 2407755

(71) Applicant: The Hospital for Sick Children
Toronto,Ontario M5G 1X8 (CA)

(72) Inventors:
  • Roifman, Chaim M.
    North York,Ontario M2R 1A4 (CA)
  • Simon, Amos J.
    56452 Yehud (IL)
  • Demini Peter M.
    Toronto,Ontario M6P 2S1 (CA)
  • Rounova, Olga B.
    Toronto,Ontario M6P 2S1 (CA)

(74) Representative: VOSSIUS & PARTNER 
Siebertstrasse 4
81675 München
81675 München (DE)

   


(54) STYRYLACRYLONITRILE COMPOUNDS FOR INHIBITION OF VASCULAR ENDOTHELIAL GROWTH FACTOR