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(11)

EP 1 551 446 A1

(12)

(43) Date of publication: 13.07.2005 Bulletin 2005/28 (21) Application number: 02744407.4 (22) Date of filing: 18.06.2002

(51) International Patent Classification (IPC)7: A61K 39/00, A61K 39/385, C12N 15/85, C12N 15/86, C12N 15/63, C07K 7/00, C07K 14/00 (86) International application number: PCT/US2002/019237 (87) International publication number: WO 2003/105892 (24.12.2003 Gazette 2003/52)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (71) Applicant: University of Kansas Medical Center Kansas City, KS 66160-7702 (US)	(72) Inventor: SHAH, Girish, V. Amarillo, TX 79109 (US) (74) Representative: Crump, Julian Richard John et al Mintz Levin Cohn Ferris Glovsky and PopeoIntellectual Property LLPThe Rectory9, Ironmonger Lane London EC2V 8EY London EC2V 8EY (GB)