(19)

(11)

EP 1 551 450 A1

(12)

(43) Date of publication: 13.07.2005 Bulletin 2005/28 (21) Application number: 03816193.1 (22) Date of filing: 12.06.2003

(51) International Patent Classification (IPC)7: A61K 39/00, A61K 39/395, A61K 47/00, G01N 33/00, G01N 33/15, G01N 33/48, G01N 33/49 (86) International application number: PCT/US2003/018780 (87) International publication number: WO 2004/078204 (16.09.2004 Gazette 2004/38)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR Designated Extension States: AL LT LV MK (30) Priority: 12.06.2002 US 388371 P (71) Applicant: The Cleveland Clinic Foundation Cleveland, OH 44195 (US)	(72) Inventors: JANIGRO, Damir Cleveland, OH 44106 (US) MARCHI, Nicola Cleveland, OH 66120 (US) (74) Representative: Ouzman, Beverley Nicola Claire et al Murgitroyd & CompanyScotland House165-169 Scotland Street Glasgow G5 8PL Glasgow G5 8PL (GB)