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EP 1 551 974 A1

(12)

(43) Date of publication: 13.07.2005 Bulletin 2005/28 (21) Application number: 03753721.4 (22) Date of filing: 03.10.2003

(51) International Patent Classification (IPC)7: C12N 15/49, C12N 15/867, A61K 39/21, C07K 14/15 (86) International application number: PCT/GB2003/004260 (87) International publication number: WO 2004/031390 (15.04.2004 Gazette 2004/16)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR Designated Extension States: AL LT LV MK (30) Priority: 04.10.2002 GB 0223076 04.12.2002 GB 0228314 04.08.2003 GB 0318213 (71) Applicant: Oxford Biomedica (UK) Limited Oxford 0X4 4GA (GB)

(72) Inventors: MAZARAKIS, NicholasOxford BioMedica (UK) Limited Oxford OX4 4GA (GB) AZZOUZ, MimounOxford BioMedica (UK) Limited Oxford OX4 4GA (GB) BINLEY, KatieOxford BioMedica (UK) Limited Oxford OX4 4GA (GB) NAYLOR, StuartOxford BioMedica (UK) Limited Oxford OX4 4GA (GB) KINGSMAN, SusanOxford BioMedica (UK) Limited Oxford OX4 4GA (GB) (74) Representative: Holliday, Louise Caroline  D Young & Co120 Holborn London EC1N 2DY London EC1N 2DY (GB)