(19)

(11)

EP 1 552 013 A1

(12)

(43) Date of publication: 13.07.2005 Bulletin 2005/28 (21) Application number: 03772000.0 (22) Date of filing: 28.07.2003

(51) International Patent Classification (IPC)7: C12Q 1/68, C12P 19/34, C12M 1/34, C07H 21/02, C07H 21/04, C07H 19/00 (86) International application number: PCT/US2003/023599 (87) International publication number: WO 2004/011681 (05.02.2004 Gazette 2004/06)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR Designated Extension States: AL LT LV MK (30) Priority: 26.07.2002 US 398778 P 26.07.2002 US 398852 P 14.04.2003 US 414179 30.04.2003 US 426587 (71) Applicant: Applera Corporation Foster City, CA 94404 (US)	(72) Inventor: HARROLD, Michael, P. San Mateo, CA 94402 (US) (74) Representative: Moran, Paula  OLSWANG90 High Holborn London WC1V 6XX London WC1V 6XX (GB)