(19)
(11) EP 1 553 955 A2

(12)

(88) Date of publication A3:
07.04.2005

(43) Date of publication:
20.07.2005 Bulletin 2005/29

(21) Application number: 03756864.9

(22) Date of filing: 24.09.2003
(51) International Patent Classification (IPC)7: A61K 31/56
(86) International application number:
PCT/US2003/030156
(87) International publication number:
WO 2004/030618 (15.04.2004 Gazette 2004/16)
(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR
Designated Extension States:
AL LT LV MK

(30) Priority: 24.09.2002 US 413040 P
09.10.2002 US 417261 P
19.11.2002 US 427526 P
19.11.2002 US 427424 P
23.04.2003 US 464753 P

(71) Applicants:
  • Combinatorx, Incorporated
    Boston, MA 02118 (US)
  • Manivasakam, Palaniyandi
    West Roxbury, Massachusetts 02132 (US)
  • Smith, Brendan
    Boston, MA 02118 (US)
  • Fong, Jason
    Philadelphia, PA 19104 (US)
  • Auspitz, Benjamin A.
    Cambridge, MA 02138 (US)
  • Nichols, M. James
    Boston, MA 02116 (US)
  • Keith, Curtis
    Boston, Massachusetts 02116 (US)
  • Zimmermann, Grant R.
    Somerville, MA 02144 (US)
  • Brasher, Bradley B.
    Natick, MA 01760 (US)
  • Sachs, Noah
    Boston, MA 02127 (US)
  • Chappell, Todd W.
    Boston, MA 02118 (US)

(72) Inventors:
  • JOST-PRICE, Edward Roydon
    West Roxbury, MA 02132 (US)
  • MANIVASAKAM, Palaniyandi
    West Roxbury, Massachusetts 02132 (US)
  • SMITH, Brendan
    Boston, MA 02118 (US)
  • FONG, Jason
    Philadelphia, PA 19104 (US)
  • AUSPITZ, Benjamin A.
    Cambridge, MA 02138 (US)
  • NICHOLS, M. James
    Boston, MA 02116 (US)
  • KEITH, Curtis
    Boston, MA 02116 (US)
  • ZIMMERMANN, Grant R.
    Somerville, MA 02144 (US)
  • BRASHER, Bradley B.
    Natick, MA 01760 (US)
  • SACHS, Noah
    Boston, MA 02127 (US)
  • CHAPPELL, Todd W.
    Boston, MA 02118 (US)

(74) Representative: Bösl, Raphael, Dr.rer.nat., Dipl.-Chem. et al
PatentanwälteIsenbruck Bösl Hörschler Wichmann HuhnPrinzregentenstrasse 68
81675 München
81675 München (DE)

   


(54) METHODS AND REAGENTS FOR THE TREATMENT OF DISEASES AND DISORDERS ASSOCIATED WITH INCREASED LEVELS OF PROINFLAMMATORY CYTOKINES