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EP 1 556 040 A1

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(43) Date of publication: 27.07.2005 Bulletin 2005/30 (21) Application number: 03758357.2 (22) Date of filing: 23.10.2003

(51) International Patent Classification (IPC)7: A61K 31/428, C07D 277/64, C07D 417/12, C07D 277/62, C07D 277/74, C07D 277/68, C07D 235/08, C07D 209/08, C07D 209/42, C07D 263/56 (86) International application number: PCT/GB2003/004590 (87) International publication number: WO 2004/037251 (06.05.2004 Gazette 2004/19)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR Designated Extension States: AL LT LV MK (30) Priority: 24.10.2002 GB 0224830 30.12.2002 US 436635 P (71) Applicant: Sterix Limited Oxford OX4 4GA (GB)

(72) Inventors: VICKER, NigelSterix Limited Oxford Science ParkOxford OX4 4GA (GB) SU, XiangdongSterix Limited Oxford Science ParkOxford OX4 4GA (GB) GANESHAPILLAI, DharshiniSterix Limited Oxford Science ParkOxford OX4 4GA (GB) PUROHIT, AtulSterix Limited Oxford Science ParkOxford OX4 4GA (GB) REED, Michael, JohnSterix Limited Oxford Science ParkOxford OX4 4GA (GB) POTTER, Barry, Victor, LloydSterix Limited Oxford Science ParkOxford OX4 4GA (GB) (74) Representative: Alcock, David  D Young & Co120 Holborn London, EC1N 2DY London, EC1N 2DY (GB)