(19)

(11)

EP 1 558 341 A2

(12)

(88) Date of publication A3: 30.09.2004 (43) Date of publication: 03.08.2005 Bulletin 2005/31 (21) Application number: 03783155.9 (22) Date of filing: 03.11.2003

(51) International Patent Classification (IPC)7: A61P 31/00, A61K 31/55, A61K 31/495, A61K 31/50, A61K 31/535, A61K 31/44, A61K 31/41, A61K 31/425, A61K 31/415, A61K 31/42, C07D 235/00 (86) International application number: PCT/US2003/035205 (87) International publication number: WO 2004/041209 (21.05.2004 Gazette 2004/21)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR Designated Extension States: AL LT LV MK (30) Priority: 01.11.2002 US 423319 P 13.11.2002 US 425916 P (71) Applicant: Paratek Pharmaceuticals, Inc. Boston, MA 02111 (US)

(72) Inventors: LEVY, Stuart, B. Boston, MA 02116 (US) ALEKSHUN, Michael, N. Wakefield, MA 01880 (US) PODLOGAR, Brent, L. Hamden, CT 06518 (US) OHEMENG, Kwasi Norwood, MA 02062 (US) VERMA, Atul, K. Mansfield, MA 02048 (US) WARCHOL, Tadeusz Northborough, MA 01532 (US) BHATIA, Beena Mansfield, MA 02048 (US) BOWSER, Todd Charlton, MA 01507 (US) GRIER, Mark Cambridge, MA 02141 (US) (74) Representative: Nash, David Allan  HASELTINE LAKE,Redcliff Quay120 Redcliff Street Bristol BS1 6HU Bristol BS1 6HU (GB)