(19)

(11)

EP 1 558 743 A2

(12)

(88) Date of publication A3: 05.08.2004 (43) Date of publication: 03.08.2005 Bulletin 2005/31 (21) Application number: 02778771.2 (22) Date of filing: 07.11.2002

(51) International Patent Classification (IPC)7: C12P 7/00, C12P 7/46, C12P 7/54, C12N 1/20, C12N 15/00, C12N 15/74 (86) International application number: PCT/US2002/035761 (87) International publication number: WO 2004/043881 (27.05.2004 Gazette 2004/22)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR Designated Extension States: AL LT LV MK RO SI (71) Applicant: UT-Battelle, LLC OAK Ridge, TN 37831-6498 (US)	(72) Inventors: NGHIEM, Nhuan, Phu Knoxville, TN 37923 (US) DONNELLY, Mark Warranville, IL 60555 (US) SANVILLE-MILLARD, Cynthia, Y. Plainfield, IL 60544 (US) (74) Representative: Ferreccio, Rinaldo  c/o Botti & Ferrari S.r.l.,Via Locatelli, 5 20124 Milano 20124 Milano (IT)