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(11)

EP 1 558 757 A1

(12)

(43) Date of publication: 03.08.2005 Bulletin 2005/31 (21) Application number: 02806779.1 (22) Date of filing: 01.11.2002

(51) International Patent Classification (IPC)7: C12Q 1/68, C12P 19/34, C07H 21/02, C07H 21/04, C07H 19/00 (86) International application number: PCT/US2002/035138 (87) International publication number: WO 2004/042086 (21.05.2004 Gazette 2004/21)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR Designated Extension States: AL LT LV MK RO SI (71) Applicant: Megabase Research Products Lincoln, NE 68504 (US)	(72) Inventors: WHITNEY, Scott E. Lincoln, NE 68504 (US) NELSON, R. Michael Lincoln, NE 68504 (US) QUINTANAR, Andre Lincoln, NE 68504 (US) VILJOEN, Hendrik J. Lincoln, NE 68504 (US) PADHYE, Nisha V. Lincoln, NE 68504 (US) (74) Representative: Price, Nigel John King  J.A. KEMP & CO.14 South SquareGray's Inn London WC1R 5JJ London WC1R 5JJ (GB)