(19)

(11)

EP 1 562 973 A2

(12)

(88) Date of publication A3: 28.04.2005 (43) Date of publication: 17.08.2005 Bulletin 2005/33 (21) Application number: 03783063.5 (22) Date of filing: 16.10.2003

(51) International Patent Classification (IPC)7: C07H 21/04, C12Q 1/68 (86) International application number: PCT/US2003/032805 (87) International publication number: WO 2004/035746 (29.04.2004 Gazette 2004/18)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR Designated Extension States: AL LT LV MK (30) Priority: 17.10.2002 US 419432 P (71) Applicant: Decode Genetics EHF. 101 Reykjavik (IS)	(72) Inventors: HELGADOTTIR, Anna IS-112 Reykjavik (IS) GULCHER, Jeffrey, R. Lake Barrington, IL 60010 (US) MANOLESCU, Andrei IS-105 Reykjavik (IS) (74) Representative: Maschio, Antonio, Dr.  D Young & Co120 Holborn London EC1N 2DY London EC1N 2DY (GB)