(19)
(11) EP 1 563 063 A2

(12)

(88) Date of publication A3:
08.07.2004

(43) Date of publication:
17.08.2005 Bulletin 2005/33

(21) Application number: 03781819.2

(22) Date of filing: 07.11.2003
(51) International Patent Classification (IPC)7C12N 9/02
(86) International application number:
PCT/US2003/035570
(87) International publication number:
WO 2004/044194 (27.05.2004 Gazette 2004/22)
(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR
Designated Extension States:
AL LT LV MK

(30) Priority: 07.11.2002 US 424653 P

(71) Applicant: Rensselaer Polytechnic Institute
Troy, NY 12180-3590 (US)

(72) Inventors:
  • SALERNO, John, C.
    Troy, NY 12180 (US)
  • SMITH, Susan, M., E.
    Troy, NY 12180 (US)

(74) Representative: Lock, Graham James et al
Fry Heath & Spence LLPThe GablesMassetts Road
Horley,Surrey RH6 7DQ
Horley,Surrey RH6 7DQ (GB)

   


(54) CALMODULIN INDEPENDENT ACTIVATION OF NITRIC OXIDE SYNTHASE BY NADPH ANALOGS