(19)
(11) EP 1 563 070 A2

(12)

(88) Date of publication A3:
14.04.2005

(43) Date of publication:
17.08.2005 Bulletin 2005/33

(21) Application number: 03786574.8

(22) Date of filing: 04.11.2003
(51) International Patent Classification (IPC)7C12N 15/11, C12Q 1/68, A61K 48/00
(86) International application number:
PCT/US2003/035087
(87) International publication number:
WO 2004/044140 (27.05.2004 Gazette 2004/22)
(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR
Designated Extension States:
AL LT LV MK

(30) Priority: 05.11.2002 US 423760 P
16.09.2003 US 503521 P

(71) Applicant: Isis Pharmaceuticals, Inc.
Carlsbad, CA 92008 (US)

(72) Inventors:
  • BAKER, Brenda
    Carlsbad, CA 92009 (US)
  • ELDRUP, Anne B.
    En cinitas, CA 92024 (DK)
  • MANOHARAN, Muthiah
    Weston, MA 02493 (US)
  • BHAT, Balkrishen
    Carlsbad, CA 92009 (US)
  • GRIFFEY, Richard
    Vista, CA 92084 (US)
  • SWAYZE, Eric, E.
    Carlsbad, CA 92009 (US)
  • CROOKE, Stanely, T.
    Carlsbad, CA 92009 (US)
  • PRAKASH, Thazha, P.
    Carlsbad, CA 92009 (US)

(74) Representative: Hallybone, Huw George et al
Carpmaels and Ransford,43-45 Bloomsbury Square
London WC1A 2RA
London WC1A 2RA (GB)

   


(54) 2'-SUBSTITUTED OLIGOMERIC COMPOUNDS AND COMPOSITIONS FOR USE IN GENE MODULATIONS