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(11)

EP 1 565 455 A1

(12)

(43) Date of publication: 24.08.2005 Bulletin 2005/34 (21) Application number: 03783328.2 (22) Date of filing: 10.11.2003

(51) International Patent Classification (IPC)7: C07D 403/04, C07D 491/04, C07D 403/14, C07D 401/14, C07D 405/14, C07D 409/14, C07D 487/04, C07D 471/04, C07D 417/14, A61K 31/498, A61K 31/5025, A61K 31/519, A61P 19/02, A61P 35/00 (86) International application number: PCT/US2003/036003 (87) International publication number: WO 2004/043950 (27.05.2004 Gazette 2004/22)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR Designated Extension States: AL LT LV MK (30) Priority: 12.11.2002 US 425490 P 07.04.2003 US 460915 P 30.06.2003 US 484202 P (71) Applicant: Bayer Pharmaceuticals Corporation West Haven, CT 06516 (US)

(72) Inventors: LADOUCEUR, Gaetan H. Guilford, CT 06437 (US) BEAR, Brian Oceanside, CA 92057 (US) BI, Cheng West Haven, CT 06516 (US) BRITTELLI, David R. Branford, CT 06405 (US) BURKE, Michael J. Cheshire, CT 06410 (US) CHEN, Gang North York, Ontario M2N 6W7 (CA) COOK, James East Hampton, CT 06424 (US) DUMAS, Jacques Bethany, CT 06524 (US) SIBLEY, Robert North Haven, CT 06473 (US) TURNER, Michael R. Milford, CT 06460 (US) (74) Representative: Linkenheil, Dieter  Bayer HealthCare AG CAO Law and Patents Patents and Licensing 51368 Leverkusen 51368 Leverkusen (DE)