(19)

(11)

EP 1 567 657 A1

(12)

(43) Date of publication: 31.08.2005 Bulletin 2005/35 (21) Application number: 03773588.3 (22) Date of filing: 24.11.2003

(51) International Patent Classification (IPC)7: C12P 21/00, C07K 1/14 (86) International application number: PCT/DK2003/000801 (87) International publication number: WO 2004/048588 (10.06.2004 Gazette 2004/24)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR Designated Extension States: AL LT LV MK (30) Priority: 26.11.2002 DK 200201821 04.12.2002 US 430748 P (71) Applicant: NOVO NORDISK A/S 2880 Bagsvaerd (DK)	(72) Inventors: MARKUSSEN, Jan DK-2730 Herlev (DK) DIERS, Ivan DK-3500 Vaerlose (DK)