(19)

(11)

EP 1 572 103 A2

(12)

(43) Date of publication: 14.09.2005 Bulletin 2005/37 (21) Application number: 03783264.9 (22) Date of filing: 10.11.2003

(51) International Patent Classification (IPC)7: A61K 6/00 (86) International application number: PCT/US2003/035651 (87) International publication number: WO 2004/045507 (03.06.2004 Gazette 2004/23)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR Designated Extension States: AL LT LV MK (30) Priority: 15.11.2002 US 426901 P (71) Applicant: CENTOCOR, INC. Malvern, PA 19355 (US)	(72) Inventors: TRIKHA, Mohit Paoli, PA 19301 (US) ZHOU, Zhao Collegeville, PA 19426 (US) (74) Representative: Mercer, Christopher Paul et al Carpmaels & Ransford, 43-45 Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)