(19)

(11)

EP 1 572 218 A2

(12)

(88) Date of publication A3: 29.12.2004 (43) Date of publication: 14.09.2005 Bulletin 2005/37 (21) Application number: 03800157.4 (22) Date of filing: 18.12.2003

(51) International Patent Classification (IPC)7: A61K 31/625, A61K 31/135, A61F 2/00 (86) International application number: PCT/US2003/041219 (87) International publication number: WO 2004/058329 (15.07.2004 Gazette 2004/29)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR Designated Extension States: AL LT LV MK (30) Priority: 20.12.2002 US 327310 (71) Applicant: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY Palo Alto, CA 94306-1106 (US)	(72) Inventor: SHAFER, Steven L. Mountain View, CA 94041 (US) (74) Representative: Brasnett, Adrian Hugh et al Mewburn Ellis LLP York House 23 Kingsway GB-London WC2B 6HP GB-London WC2B 6HP (GB)