(19)

(11)

EP 1 572 904 A2

(12)

(43) Date of publication: 14.09.2005 Bulletin 2005/37 (21) Application number: 03709301.0 (22) Date of filing: 21.02.2003

(51) International Patent Classification (IPC)7: C12N 1/00 (86) International application number: PCT/US2003/005508 (87) International publication number: WO 2003/072733 (04.09.2003 Gazette 2003/36)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT SE SI SK TR (30) Priority: 21.02.2002 US 358651 P (71) Applicant: Pharmacia & Upjohn Company LLC Kalamazoo, MI 49001 (US)	(72) Inventors: CHOU, Kuo-Chen Kalamazoo, MI 49009 (US) HOWE, Jeffrey, W. Brighton, MI 48116-5181 (US) (74) Representative: Schweitzer, Klaus  Patentanwaltskanzlei Zounek Industriepark Kalle-Albert Gebäude H391 Rheingaustrasse 190-196 65174 Wiesbaden 65174 Wiesbaden (DE)