(19)

(11)

EP 1 576 151 A2

(12)

(88) Date of publication A3: 28.07.2005 (43) Date of publication: 21.09.2005 Bulletin 2005/38 (21) Application number: 03817367.0 (22) Date of filing: 06.08.2003

(51) International Patent Classification (IPC)7: C12N 9/00, C12N 1/20, C12N 15/00, C12Q 1/00, C12Q 1/34, C12Q 1/68, C12P 21/06, C12P 21/04, A61K 38/44, C07H 21/04, C07K 1/00 (86) International application number: PCT/US2003/024671 (87) International publication number: WO 2005/003289 (13.01.2005 Gazette 2005/02)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR Designated Extension States: AL LT LV MK (30) Priority: 06.08.2002 US 401629 P 13.06.2003 US 478188 P (71) Applicants: Verdia, Inc. Redwood City, CA 94063 (US) PIONEER HI-BRED INTERNATIONAL, INC. Johnston, Iowa 50131-1014 (US)	(72) Inventors: CHATTERJEE, Ranjini Belmont, CA 94002 (US) DUVICK, Jonathan, P. Des Moines, IA 50310 (US) ENGLISH, James Burlingame, CA 94010 (US) (74) Representative: Bentham, Andrew  J.A. Kemp & Co. 14 South Square Gray's Inn London WC1R 5JJ London WC1R 5JJ (GB)