(19)
(11) EP 1 576 154 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
13.04.2011 Bulletin 2011/15

(45) Mention of the grant of the patent:
23.02.2011 Bulletin 2011/08

(21) Application number: 03779576.2

(22) Date of filing: 18.12.2003
(51) International Patent Classification (IPC): 
C12N 15/10(2006.01)
 C12N 15/63(2006.01)
(86) International application number:
PCT/AU2003/001697
(87) International publication number:
WO 2004/055182 (01.07.2004 Gazette 2004/27)

(54)

IN VIVO AFFINITY MATURATION SCHEME

IN-VIVO AFFINITÄTSREIFUNGSSCHEMA

SCHEMA DE MATURATION PAR AFFINITE IN VIVO

(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR

(30) Priority: 18.12.2002 AU 2002953381

(43) Date of publication of application:
21.09.2005 Bulletin 2005/38

(73) Proprietor: AnaptysBio, Inc.
San Diego, CA 92121 (US)

(72) Inventors:
  • IRVING, Robert, Alexander
    Wheelers Hill, Victoria 3150 (AU)
  • HUDSON, Peter, John
    Blackburn, Victoria 3130 (AU)
  • MUSTAFA, Huseyin
    Glenroy, Victoria 3046 (AU)
  • WARK, Kim
    Elwood, Victoria 3184 (AU)
  • ABREGU, Matias, Ezequiel
    St. Albans, Victoria 3021 (AU)

(74) Representative: Brasnett, Adrian Hugh et al
Mewburn Ellis LLP 33 Gutter Lane
London EC2V 8AS
London EC2V 8AS (GB)


(56) References cited: : 
WO-A-00/22111
US-A- 5 885 827
 US-A- 5 885 827
   
  • YELAMOS J ET AL: "Targeting of non-lg sequences in place of the V segment by somatic hypermutation" NATURE, NATURE PUBLISHING GROUP, LONDON, GB, vol. 376, no. 6537, 1995, pages 225-229, XP002211125 ISSN: 0028-0836
  • MARTIN ET AL: "Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas" NATURE, NATURE PUBLISHING GROUP, LONDON, GB, vol. 415, 14 February 2002 (2002-02-14), pages 802-806, XP002253537 ISSN: 0028-0836
  • YELAMOS J. ET AL.: 'Targeting of non-Ig sequences in place of the V segment by somatic hypermutation' NATURE vol. 376, 1995, pages 225 - 229, XP002211125
  • MARTIN A, SCHARFF M. D.: 'Somatic hypermutation of the AID transgene in B and non-B cells' PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES USA vol. 99, no. 19, 2002, pages 12304 - 12308, XP002964738
  • IRVING R. A. ET AL.: 'Affinity maturation of recombinant antibodies using E.coli mutator cells' IMMUNOTECHNOLOGY vol. 2, 1996, pages 127 - 143, XP000612236
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).