(19)

(11)

EP 1 576 371 A1

(12)

(43) Date of publication: 21.09.2005 Bulletin 2005/38 (21) Application number: 03778503.7 (22) Date of filing: 24.11.2003

(51) International Patent Classification (IPC)7: G01N 33/569, G01N 33/68 (86) International application number: PCT/GB2003/005084 (87) International publication number: WO 2004/055516 (01.07.2004 Gazette 2004/27)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR Designated Extension States: AL LT LV MK (30) Priority: 18.12.2002 GB 0229444 (71) Applicant: Royal Free Hampstead NHS Trust London NW3 2QG (GB)	(72) Inventor: BARRY, Simon Lewes,East Sussex BN7 1TY (GB) (74) Representative: Jenkins, Peter David et al PAGE WHITE & FARRER 54 Doughty Street London WC1N 2LS London WC1N 2LS (GB)