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EP 1 578 716 A1

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(43) Date of publication: 28.09.2005 Bulletin 2005/39 (21) Application number: 03779752.9 (22) Date of filing: 18.12.2003

(51) International Patent Classification (IPC)7: C07C 59/68, C07C 69/612, C07C 69/734, C07C 229/36, C07D 333/10, C07D 213/24, C07D 487/04, A61P 3/10, A61P 3/04, A61K 31/215, A61K 31/216, A61K 31/381, A61K 31/341, A61K 31/395, A61K 31/225 (86) International application number: PCT/DK2003/000895 (87) International publication number: WO 2004/056740 (08.07.2004 Gazette 2004/28)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR Designated Extension States: AL LT LV MK (30) Priority: 20.12.2002 DK 200201966 (71) Applicant: NOVO NORDISK A/S 2880 Bagsvaerd (DK)	(72) Inventors: SAUERBERG, Per DK-3520 Farum (DK) JEPPESEN, Lone DK-2830 Virum (DK) POLIVKA, Zdenek 150 00 Praha 5 (CZ) SINDELAR, Karel 140 00 Praha 4 (CZ) (74) Representative: Madsen, Inger Margrethe Schelde  c/o Novo Nordisk A/S, Patent Department, Novo Allé 2880 Bagsvaerd 2880 Bagsvaerd (DK)