| (84) |
Designated Contracting States: |
|
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR |
| (30) |
Priority: |
17.04.2001 US 837306
24.10.2001 US 516
25.10.2001 US 45674
|
| (43) |
Date of publication of application: |
|
28.09.2005 Bulletin 2005/39 |
| (73) |
Proprietor: Dyax Corp. |
|
Cambridge, MA 02139 (US) |
|
| (72) |
Inventors: |
|
- LADNER, Robert C.
Ijamsville, MD 21754 (US)
- COHEN, Edward H.
Belmont, MA 02478 (US)
- NASTRI, Horacio G.
Needham, MA 02492 (US)
- ROOKEY, Kristin L.
Revere, MA 02151 (US)
- HOET, René
6226 CZ Maastricht (NL)
- HOOGENBOOM, Hendricus R.J.M.
6214 AE Maastricht (NL)
|
| (74) |
Representative: Vossius & Partner |
|
Siebertstrasse 4
81675 München
81675 München (DE) |
| (56) |
References cited: :
DE-A1- 19 624 562
US-A- 5 380 833
US-A- 5 798 208
US-A- 5 858 671
|
US-A- 5 223 409
US-A- 5 688 666
US-A- 5 846 765
US-A- 5 969 108
|
|
| |
|
|
- DAVIES J ET AL: "Affinity improvement of single antibody VH domains: residues in all
three hypervariable regions affect antigen binding" IMMUNOTECHNOLOGY, ELSEVIER SCIENCE
PUBLISHERS BV, NL, vol. 2, no. 3, September 1996 (1996-09), pages 169-179, XP004070292
ISSN: 1380-2933
- ARDEN B: "Conserved motifs in T-cell receptor CDR1 and CDR2: implications for ligand
and CD8 co-receptor binding" CURRENT OPINION IN IMMUNOLOGY, CURRENT BIOLOGY LTD, vol.
10, no. 1, February 1998 (1998-02), pages 74-81, XP004313624 ISSN: 0952-7915
- HOOGENBOOM H R ET AL: "By-passing Immunisation - Human Antibodies from Synthetic Repertoires
of Germline VH Gene Segments Rearranged in Vitro" JOURNAL OF MOLECULAR BIOLOGY, LONDON,
GB, vol. 227, 1992, pages 381-388, XP002974448 ISSN: 0022-2836
- DE HAARD H J ET AL: "A large non-immunized human Fab fragment phage library that permits
rapid isolation and kinetic analysis of high affinity antibodies" JOURNAL OF BIOLOGICAL
CHEMISTRY, AMERICAN SOCIETY OF BIOLOCHEMICAL BIOLOGISTS, BIRMINGHAM,, US, vol. 274,
no. 26, 25 June 1999 (1999-06-25), pages 18218-18230, XP002128301 ISSN: 0021-9258
- TOMLINSON I M ET AL: "THE REPERTOIRE OF HUMAN GERMLINE VH SEQUENCES REVEALS ABOUT
FIFTY GROUPS OF VH SEGMENTS WITH DIFFERENT HYPERVARIABLE LOOPS" JOURNAL OF MOLECULAR
BIOLOGY, LONDON, GB, vol. 227, 1992, pages 776-798, XP000990787 ISSN: 0022-2836
- BARBAS S M ET AL: "HUMAN AUTOANTIBODY RECOGNITION OF DNA" PROCEEDINGS OF THE NATIONAL
ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, vol.
92, March 1995 (1995-03), pages 2529-2533, XP002927212 ISSN: 0027-8424
|
|
