(19)

(11)

EP 1 578 927 A2

(12)

(43) Date of publication: 28.09.2005 Bulletin 2005/39 (21) Application number: 03749047.1 (22) Date of filing: 14.08.2003

(51) International Patent Classification (IPC)7: C12N 1/00 (86) International application number: PCT/US2003/025465 (87) International publication number: WO 2004/016754 (26.02.2004 Gazette 2004/09)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR Designated Extension States: AL LT LV MK (30) Priority: 14.08.2002 US 403416 P (71) Applicant: Pharmacia Corporation Chesterfield, MO 63017-1732 (US)	(72) Inventor: ROBERDS, Steven, L. Mattawan, MI 49071 (US) (74) Representative: Courgeon, Antoine  Pfizer European Pharma Patent Department 23-25, avenue du Docteur Lannelongue 75668 Paris Cedex 14 75668 Paris Cedex 14 (FR)