(19)
(11) EP 1 579 222 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
07.01.2009 Bulletin 2009/02

(45) Mention of the grant of the patent:
10.09.2008 Bulletin 2008/37

(21) Application number: 03773761.6

(22) Date of filing: 17.11.2003
(51) International Patent Classification (IPC): 
G01N 33/94(2006.01)
G01N 33/53(2006.01)
(86) International application number:
PCT/FI2003/000875
(87) International publication number:
WO 2004/046733 (03.06.2004 Gazette 2004/23)

(54)

NON-COMPETITIVE IMMUNOASSAY FOR SMALL ANALYTES

NICHTKOMPETITIVER IMMUNASSAY FÜR KLEINE ANALYTEN

DOSAGE IMMUNOLOGIQUE NON COMPETITIF POUR SUBSTANCES A ANALYSER DE TAILLE REDUITE


(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR
Designated Extension States:
LT LV

(30) Priority: 18.11.2002 FI 20022048

(43) Date of publication of application:
28.09.2005 Bulletin 2005/39

(73) Proprietor: VALTION TEKNILLINEN TUTKIMUSKESKUS
02150 Espoo (FI)

(72) Inventors:
  • PULLI, Timo
    FIN-00650 Helsinki (FI)
  • HÖYHTYÄ, Matti
    FIN-00100 Helsinki (FI)
  • TAKKINEN, Kristiina
    FIN-02200 Espoo (FI)
  • SÖDERLUND, Hans
    FIN-02940 Espoo (FI)

(74) Representative: Boije-Backman, Solveig Magdalena 
Kolster Oy Ab, Iso Roobertinkatu 23, P.O. Box 148
00121 Helsinki
00121 Helsinki (FI)


(56) References cited: : 
US-A- 3 996 345
US-B1- 6 326 159
   
  • ULLMAN EDWIN F. ET AL.: 'Anti-immune complex antibodies enhance affinity and specificity of primary antibodies' PROC. NATL. ACAD. SCI. USA vol. 90, February 1993, pages 1184 - 1189, XP002974350
  • RYOICHI ARAI ET AL.: 'Fluorolabeling of antibody variable domains with green fluorescent protein variants: application to an energy transferbased homogeneous immunoassay' PROTEIN ENGINEERING vol. 13, no. 5, 2000, pages 369 - 376, XP001035160
  • DATABASE WPI Week 200155, Derwent Publications Ltd., London, GB; Class B04, AN 2001-499659, XP002974351 & JP 2001 174460 A (TOSOH CORP) 29 June 2001
  • LITTLE MELVYN ET AL.: 'Generation of a large complex antibody library from multiple donors' JOURNAL OF IMMUNOLOGICAL METHODS vol. 231, 1999, pages 3 - 9, XP002941689
  • CHARLTON K. ET AL.: 'The isolation of super-sensitive anti-hapten antibodies from combinatorial antibody libraries derived from sheep' BIOSENSORS & BIOELECTRONICS vol. 16, 2001, pages 639 - 646, XP002974352
  • BOLGER MICHAEL B. ET AL.: 'Preparation and characterization of antisera and monoclonal antibodies to haloperidol' IMMUNOLOGICAL INVESTIGATIONS vol. 14, no. 6, 1985, pages 523 - 540, XP002974353
  • [Online] Retrieved from the Internet: URL:http://www.sciencedirect.com/science?_ ob=ArticleURL&_udi=B6X0P-475RFDD-3&_coverD ate=03%2F25%2F2003&_alid=430668242&_rdoc=1 &_fmt=&_orig=search&_qd=1&_cdi=7220&_sort= d&view=c&_acct=C000049880&_version=1&_urlV ersion=0&_userid=987766&md5=0414d89ffcb6a2 b62248cfcccfa8aa1c> [retrieved on 2006-08-02]
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).