(19)

(11)

EP 1 581 218 A1

(12)

(43) Date of publication: 05.10.2005 Bulletin 2005/40 (21) Application number: 03785751.3 (22) Date of filing: 05.12.2003

(51) International Patent Classification (IPC)7: A61K 31/427, C07D 417/14, C07D 493/04, A61P 35/00 (86) International application number: PCT/EP2003/013780 (87) International publication number: WO 2004/050089 (17.06.2004 Gazette 2004/25)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR Designated Extension States: AL LT LV MK (30) Priority: 05.12.2002 DE 10256982 06.12.2002 US 431197 P (71) Applicant: Schering AG 13353 Berlin (DE)	(72) Inventors: BOSSLET, Klaus 13465 Berlin (DE) HESS-STUMPP, Holger 13507 Berlin (DE) HOFFMANN, Jens 16567 Mühlenbeck (DE) KLAR, Ulrich 13503 Berlin (DE) ROTGERI, Andrea 13503 Berlin (DE) (74) Representative: Dörries, Hans Ulrich  Dörries, Frank-Molnia & Pohlman, Triftstrasse 13 80538 München 80538 München (DE)