(19)

(11)

EP 1 581 637 A2

(12)

(88) Date of publication A3: 03.02.2005 (43) Date of publication: 05.10.2005 Bulletin 2005/40 (21) Application number: 03781813.5 (22) Date of filing: 07.11.2003

(51) International Patent Classification (IPC)7: C12N 5/00, C12N 5/02, C12N 5/08, A61K 35/26, A61K 35/28 (86) International application number: PCT/US2003/035538 (87) International publication number: WO 2004/043990 (27.05.2004 Gazette 2004/22)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR (30) Priority: 07.11.2002 US 424442 P (71) Applicant: UNIVERSITY OF CHICAGO Chicago, IL 60637 (US)	(72) Inventors: HUBERMAN, Eliezer Chicago, IL 60610 (US) ZHAO, Yong Hinsdale, IL 60521 (US) (74) Representative: Findeisen, Marco et al Witte, Weller & Partner Patentanwälte Postfach 105462 70047 Stuttgart 70047 Stuttgart (DE)