(19)

(11)

EP 1 583 765 A2

(12)

(88) Date of publication A3: 18.08.2005 (43) Date of publication: 12.10.2005 Bulletin 2005/41 (21) Application number: 03796428.5 (22) Date of filing: 18.11.2003

(51) International Patent Classification (IPC)7: C07F 9/00 (86) International application number: PCT/US2003/037037 (87) International publication number: WO 2004/045552 (03.06.2004 Gazette 2004/23)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR Designated Extension States: AL LT LV MK (30) Priority: 18.11.2002 US 427105 P 18.11.2002 US 427104 P 18.11.2002 US 427201 P 18.11.2002 US 427203 P 20.03.2003 US 456345 P 17.11.2003 US 336749 P (71) Applicant: Grenpharma LLC Waltham, MA 02454 (US)	(72) Inventors: FRIEDMAN, Orrie Brookline, MA 02445 (US) CORREIA, Ivan Winchester, MA 01890 (US) SOMMER, Toby Waltham, MA 02454-1092 (US) KEW, David, Alan Worcester, MA 01605 (US) (74) Representative: Killin, Stephen James et al Venner Shipley LLP 20 Little Britain London EC1A 7DH London EC1A 7DH (GB)