(19)

(11)

EP 1 585 547 A2

(12)

(88) Date of publication A3: 09.12.2004 (43) Date of publication: 19.10.2005 Bulletin 2005/42 (21) Application number: 03808561.9 (22) Date of filing: 22.12.2003

(51) International Patent Classification (IPC)7: A61K 39/395 (86) International application number: PCT/US2003/041243 (87) International publication number: WO 2004/058183 (15.07.2004 Gazette 2004/29)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR Designated Extension States: AL LT LV MK (30) Priority: 20.12.2002 US 435185 P (71) Applicant: Biogen Idec MA Inc. Cambridge, Massachusetts 02142 (US)	(72) Inventors: LEPAGE, Doreen Pascoag, RI 02859 (US) GILL, Alan Reading, MA 01867-3959 (US) (74) Representative: Adams, Harvey Vaughan John et al Mathys & Squire, 120 Holborn London EC1N 2SQ London EC1N 2SQ (GB)