(19)
(11) EP 1 585 966 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
07.03.2012 Bulletin 2012/10

(45) Mention of the grant of the patent:
30.11.2011 Bulletin 2011/48

(21) Application number: 03755724.6

(22) Date of filing: 11.07.2003
(51) International Patent Classification (IPC): 
A61K 39/395(2006.01)
(86) International application number:
PCT/US2003/021590
(87) International publication number:
WO 2004/008099 (22.01.2004 Gazette 2004/04)

(54)

Treatment of cancer with the anti-ErbB2 antibody rhuMAb 2C4

Behandlung von Krebs mit dem anti-ErbB2-Antikörper rhuMAb 2C4

Traitment de cancer par l'anticorps rhuMAb 2C4


(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR

(30) Priority: 15.07.2002 US 396290 P
20.06.2003 US 480043 P

(43) Date of publication of application:
19.10.2005 Bulletin 2005/42

(60) Divisional application:
10176072.6 / 2263691

(73) Proprietor: F.Hoffmann-La Roche AG
4070 Basel (CH)

(72) Inventors:
  • KOLL, Hans
    85247 Oberroth (DE)
  • BOSSENMAIER, Birgit
    82229 Seefeld (DE)
  • MÜLLER, Hans-Joachim
    82377 Penzberg (DE)
  • SLIWKOWSKI, Mark, X.
    San Carlos, CA 94070 (US)
  • KELSEY, Stephen, Michael
    Montara, CA 94037 (US)

(74) Representative: Walton, Seán Malcolm et al
Mewburn Ellis LLP 33 Gutter Lane
London EC2V 8AS
London EC2V 8AS (GB)


(56) References cited: : 
WO-A-01/00245
WO-A-01/89566
US-A- 5 811 098
US-B1- 6 417 168
WO-A-01/09186
US-A- 5 811 098
US-A1- 2002 064 805
US-B1- 6 417 168
   
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  • GILBERTSON RICHARD J ET AL: "Prognostic significance of HER2 and HER4 coexpression in childhood medulloblastoma" CANCER RESEARCH, vol. 57, no. 15, 1997, pages 3272-3280, XP008069241 ISSN: 0008-5472
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  • LYNE J C ET AL: "Tissue expression of neu differentiation factor/heregulin and its receptor complex in prostate cancer and its biologic effects on prostate cancer cells in vitro." THE CANCER JOURNAL FROM SCIENTIFIC AMERICAN. 1997 JAN-FEB, vol. 3, no. 1, January 1997 (1997-01), pages 21-30, XP002400088 ISSN: 1081-4442
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  • MOTOYAMA ANDREA B ET AL: "The efficacy of ErbB receptor-targeted anticancer therapeutics is influenced by the availability of epidermal growth factor-related peptides" CANCER RESEARCH, vol. 62, no. 11, 11 June 2002 (2002-06-11), pages 3151-3158, XP001155498 ISSN: 0008-5472
  • CHEN XINMEI ET AL: "Enhanced drug resistance in cells coexpressing ErbB2 with EGF receptor or ErbB3" BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 277, no. 3, 2 November 2000 (2000-11-02), pages 757-763, XP002400090 ISSN: 0006-291X
  • BROCKHOFF GERO ET AL: "Epidermal growth factor receptor, c-erbB2 and c-erbB3 receptor interaction, and related cell cycle kinetics of SK-BR-3 and BT474 breast carcinoma cells" CYTOMETRY, vol. 44, no. 4, 1 August 2001 (2001-08-01), pages 338-348, XP002400091 ISSN: 0196-4763
  • NEVE RICHARD M ET AL: "Effects of oncogenic ErbB2 on G1 cell cycle regulators in breast tumour cells" ONCOGENE, vol. 19, no. 13, 23 March 2000 (2000-03-23), pages 1647-1656, XP002400092 ISSN: 0950-9232
  • AGUS D.B. ET AL: 'Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growth' CANCER CELL vol. 2, August 2002, pages 127 - 137, XP002988666
  • TZAHAR E. ET AL: 'The ErbB-2/HER2 oncogenic receptor of adenocarcinomas: from orphanhood to multiple stromal ligands' BIOCHEMICA ET BIOPHYSICA ACTA vol. 1377, 20 February 1998, pages M29 - M34, XP004281795
  • SLIKOWSKI M.X. ET AL: 'Coexpression of erbB2 and erbB3 proteins reconstitutes a high affinity receptor for heregulin' THE JOURNAL OF BIOLOGICAL CHEMISTRY vol. 269, no. 20, 20 May 1994, pages 14661 - 14665, XP000605388
  • QIAN X. ET AL: 'p185c-neu and Epidermal Growth Factor Receptor Associated into Structure Composed of Activated Kinases' PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES vol. 89, February 1992, pages 1330 - 1334, XP002988667
  • GORDON MICHAEL S ET AL: "Clinical activity of pertuzumab (rhuMAb 2C4), a HER dimerization inhibitor, in advanced ovarian cancer: potential predictive relationship with tumor HER2 activation status", JOURNAL OF CLINICAL ONCOLOGY, AMERICAN SOCIETY OF CLINICAL ONCOLOGY, US, vol. 24, no. 26, 10 September 2006 (2006-09-10), pages 4324-4332, XP002492090, ISSN: 0732-183X, DOI: DOI:10.1200/JCO.2005.05.4221 [retrieved on 2006-08-07]
  • BASELGA, J. ET AL.: "Objective response rate in a phase II multicenter trial of pertuzumab (P), a HER2 dimerization inhibiting monoclonal antibody, in combination with trastuuzumab (T) in patients (pts) with HER2-positive metastatic breast cancer (MBC) which as progressed during treatment with T", JOURNAL OF CLINICAL ONCOLOGY, vol. 25, no. 18S, 20 June 2007 (2007-06-20), page 1004,
  • MAKHIJA, S. ET AL.: "Results from a phase II randomzied, placebo-controlled, double-blind trial suggest improved PFS with the addition of pertuzumab to gemcitabine in patients with platinum-resistant ovarian, fallopian tube, or primary peritoneal cancer", JOURNAL OF CLINICAL ONCOLOGY, vol. 25, no. 18S, 20 June 2007 (2007-06-20), page 5507,
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  • ALLISON, D. ET AL,: "Pharmacokinetics (PK) of Pertuzumab (rhuMAb 2C4) in Phase II Studies of Ovarian, Breast, Prostate, and Lung Cancers", , 2005, page 2532,
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).