<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE ep-patent-document PUBLIC "-//EPO//EP PATENT DOCUMENT 1.4//EN" "ep-patent-document-v1-4.dtd">
<ep-patent-document id="EP03755724B8W1" file="EP03755724W1B8.xml" lang="en" country="EP" doc-number="1585966" kind="B8" correction-code="W1" date-publ="20120307" status="c" dtd-version="ep-patent-document-v1-4">
<SDOBI lang="en"><B000><eptags><B001EP>ATBECHDEDKESFRGBGRITLILUNLSEMCPTIESI....FIRO..CY..TRBGCZEEHU..SK....................................</B001EP><B003EP>*</B003EP><B005EP>J</B005EP><B007EP>DIM360 Ver 2.15 (14 Jul 2008) -  2999001/0</B007EP></eptags></B000><B100><B110>1585966</B110><B120><B121>CORRECTED EUROPEAN PATENT SPECIFICATION</B121></B120><B130>B8</B130><B132EP>B1</B132EP><B140><date>20120307</date></B140><B150><B151>W1</B151><B153>73</B153><B155><B1551>de</B1551><B1552>Bibliographie</B1552><B1551>en</B1551><B1552>Bibliography</B1552><B1551>fr</B1551><B1552>Bibliographie</B1552></B155></B150><B190>EP</B190></B100><B200><B210>03755724.6</B210><B220><date>20030711</date></B220><B240><B241><date>20050204</date></B241><B242><date>20070718</date></B242></B240><B250>en</B250><B251EP>en</B251EP><B260>en</B260></B200><B300><B310>396290 P</B310><B320><date>20020715</date></B320><B330><ctry>US</ctry></B330><B310>480043 P</B310><B320><date>20030620</date></B320><B330><ctry>US</ctry></B330></B300><B400><B405><date>20120307</date><bnum>201210</bnum></B405><B430><date>20051019</date><bnum>200542</bnum></B430><B450><date>20111130</date><bnum>201148</bnum></B450><B452EP><date>20110517</date></B452EP><B480><date>20120307</date><bnum>201210</bnum></B480></B400><B500><B510EP><classification-ipcr sequence="1"><text>A61K  39/395       20060101AFI20060110BHEP        </text></classification-ipcr></B510EP><B540><B541>de</B541><B542>Behandlung von Krebs mit dem anti-ErbB2-Antikörper rhuMAb 2C4</B542><B541>en</B541><B542>Treatment of cancer with the anti-ErbB2 antibody rhuMAb 2C4</B542><B541>fr</B541><B542>Traitment de cancer par l'anticorps rhuMAb 2C4</B542></B540><B560><B561><text>WO-A-01/00245</text></B561><B561><text>WO-A-01/09186</text></B561><B561><text>WO-A-01/89566</text></B561><B561><text>US-A- 5 811 098</text></B561><B561><text>US-A- 5 811 098</text></B561><B561><text>US-A1- 2002 064 805</text></B561><B561><text>US-B1- 6 417 168</text></B561><B561><text>US-B1- 6 417 168</text></B561><B562><text>XIA W ET AL: "Combination of EGFR, HER-2/neu, and HER-3 is a stronger predictor for the outcome of oral squamous cell carcinoma than any individual family members." CLINICAL CANCER RESEARCH : AN OFFICIAL JOURNAL OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH. DEC 1999, vol. 5, no. 12, December 1999 (1999-12), pages 4164-4174, XP002400085 ISSN: 1078-0432</text></B562><B562><text>GILBERTSON RICHARD J ET AL: "Prognostic significance of HER2 and HER4 coexpression in childhood medulloblastoma" CANCER RESEARCH, vol. 57, no. 15, 1997, pages 3272-3280, XP008069241 ISSN: 0008-5472</text></B562><B562><text>LANE HEIDI A ET AL: "ErbB2 potentiates breast tumor proliferation through modulation of p27Kip1-Cdk2 complex formation: Receptor overexpression does not determine growth dependency" MOLECULAR AND CELLULAR BIOLOGY, vol. 20, no. 9, May 2000 (2000-05), pages 3210-3223, XP002400087 ISSN: 0270-7306</text></B562><B562><text>LYNE J C ET AL: "Tissue expression of neu differentiation factor/heregulin and its receptor complex in prostate cancer and its biologic effects on prostate cancer cells in vitro." THE CANCER JOURNAL FROM SCIENTIFIC AMERICAN. 1997 JAN-FEB, vol. 3, no. 1, January 1997 (1997-01), pages 21-30, XP002400088 ISSN: 1081-4442</text></B562><B562><text>OLAYIOYE M: "The Erbbeta Signaling Network: Receptor Heterodimerization in Development and Cancer" EMBO JOURNAL, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 19, no. 13, January 2000 (2000-01), pages 3159-3167, XP002985171 ISSN: 0261-4189</text></B562><B562><text>MOTOYAMA ANDREA B ET AL: "The efficacy of ErbB receptor-targeted anticancer therapeutics is influenced by the availability of epidermal growth factor-related peptides" CANCER RESEARCH, vol. 62, no. 11, 11 June 2002 (2002-06-11), pages 3151-3158, XP001155498 ISSN: 0008-5472</text></B562><B562><text>CHEN XINMEI ET AL: "Enhanced drug resistance in cells coexpressing ErbB2 with EGF receptor or ErbB3" BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 277, no. 3, 2 November 2000 (2000-11-02), pages 757-763, XP002400090 ISSN: 0006-291X</text></B562><B562><text>BROCKHOFF GERO ET AL: "Epidermal growth factor receptor, c-erbB2 and c-erbB3 receptor interaction, and related cell cycle kinetics of SK-BR-3 and BT474 breast carcinoma cells" CYTOMETRY, vol. 44, no. 4, 1 August 2001 (2001-08-01), pages 338-348, XP002400091 ISSN: 0196-4763</text></B562><B562><text>NEVE RICHARD M ET AL: "Effects of oncogenic ErbB2 on G1 cell cycle regulators in breast tumour cells" ONCOGENE, vol. 19, no. 13, 23 March 2000 (2000-03-23), pages 1647-1656, XP002400092 ISSN: 0950-9232</text></B562><B562><text>AGUS D.B. ET AL: 'Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growth' CANCER CELL vol. 2, August 2002, pages 127 - 137, XP002988666</text></B562><B562><text>TZAHAR E. ET AL: 'The ErbB-2/HER2 oncogenic receptor of adenocarcinomas: from orphanhood to multiple stromal ligands' BIOCHEMICA ET BIOPHYSICA ACTA vol. 1377, 20 February 1998, pages M29 - M34, XP004281795</text></B562><B562><text>SLIKOWSKI M.X. ET AL: 'Coexpression of erbB2 and erbB3 proteins reconstitutes a high affinity receptor for heregulin' THE JOURNAL OF BIOLOGICAL CHEMISTRY vol. 269, no. 20, 20 May 1994, pages 14661 - 14665, XP000605388</text></B562><B562><text>QIAN X. ET AL: 'p185c-neu and Epidermal Growth Factor Receptor Associated into Structure Composed of Activated Kinases' PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES vol. 89, February 1992, pages 1330 - 1334, XP002988667</text></B562><B562><text>GORDON MICHAEL S ET AL: "Clinical activity of pertuzumab (rhuMAb 2C4), a HER dimerization inhibitor, in advanced ovarian cancer: potential predictive relationship with tumor HER2 activation status", JOURNAL OF CLINICAL ONCOLOGY, AMERICAN SOCIETY OF CLINICAL ONCOLOGY, US, vol. 24, no. 26, 10 September 2006 (2006-09-10), pages 4324-4332, XP002492090, ISSN: 0732-183X, DOI: DOI:10.1200/JCO.2005.05.4221 [retrieved on 2006-08-07]</text></B562><B562><text>BASELGA, J. ET AL.: "Objective response rate in a phase II multicenter trial of pertuzumab (P), a HER2 dimerization inhibiting monoclonal antibody, in combination with trastuuzumab (T) in patients (pts) with HER2-positive metastatic breast cancer (MBC) which as progressed during treatment with T", JOURNAL OF CLINICAL ONCOLOGY, vol. 25, no. 18S, 20 June 2007 (2007-06-20), page 1004,</text></B562><B562><text>MAKHIJA, S. ET AL.: "Results from a phase II randomzied, placebo-controlled, double-blind trial suggest improved PFS with the addition of pertuzumab to gemcitabine in patients with platinum-resistant ovarian, fallopian tube, or primary peritoneal cancer", JOURNAL OF CLINICAL ONCOLOGY, vol. 25, no. 18S, 20 June 2007 (2007-06-20), page 5507,</text></B562><B562><text>CHEE M NG ET AL: "Rationale for Fixed Dosing of Pertuzumab in Cancer Patients Based on Population Pharmacokinetic Analysis", PHARMACEUTICAL RESEARCH, KLUWER ACADEMIC PUBLISHERS-PLENUM PUBLISHERS, NL, vol. 23, no. 6, 26 May 2006 (2006-05-26), pages 1275-1284, XP019405128, ISSN: 1573-904X, DOI: DOI:10.1007/S11095-006-0205-X</text></B562><B562><text>ALLISON, D. ET AL,: "Pharmacokinetics (PK) of Pertuzumab (rhuMAb 2C4) in Phase II Studies of Ovarian, Breast, Prostate, and Lung Cancers", , 2005, page 2532,</text></B562><B565EP><date>20070122</date></B565EP></B560></B500><B600><B620EP><parent><cdoc><dnum><anum>10176072.6</anum><pnum>2263691</pnum></dnum><date>20100909</date></cdoc></parent></B620EP></B600><B700><B720><B721><snm>KOLL, Hans</snm><adr><str>Blütenanger 45</str><city>85247 Oberroth</city><ctry>DE</ctry></adr></B721><B721><snm>BOSSENMAIER, Birgit</snm><adr><str>Horst-Wolfram-Geissler-Weg 10</str><city>82229 Seefeld</city><ctry>DE</ctry></adr></B721><B721><snm>MÜLLER, Hans-Joachim</snm><adr><str>Ruhe am Bach 5 b</str><city>82377 Penzberg</city><ctry>DE</ctry></adr></B721><B721><snm>SLIWKOWSKI, Mark, X.</snm><adr><str>42 Oak Creek Lane</str><city>San Carlos, CA 94070</city><ctry>US</ctry></adr></B721><B721><snm>KELSEY, Stephen, Michael</snm><adr><str>360 14th Street</str><city>Montara, CA 94037</city><ctry>US</ctry></adr></B721></B720><B730><B731><snm>F.Hoffmann-La Roche AG</snm><iid>100120526</iid><irf>SMW/FP6271563</irf><adr><str>Grenzacherstrasse 124</str><city>4070 Basel</city><ctry>CH</ctry></adr></B731></B730><B740><B741><snm>Walton, Seán Malcolm</snm><sfx>et al</sfx><iid>100036945</iid><adr><str>Mewburn Ellis LLP 
33 Gutter Lane</str><city>London
EC2V 8AS</city><ctry>GB</ctry></adr></B741></B740></B700><B800><B840><ctry>AT</ctry><ctry>BE</ctry><ctry>BG</ctry><ctry>CH</ctry><ctry>CY</ctry><ctry>CZ</ctry><ctry>DE</ctry><ctry>DK</ctry><ctry>EE</ctry><ctry>ES</ctry><ctry>FI</ctry><ctry>FR</ctry><ctry>GB</ctry><ctry>GR</ctry><ctry>HU</ctry><ctry>IE</ctry><ctry>IT</ctry><ctry>LI</ctry><ctry>LU</ctry><ctry>MC</ctry><ctry>NL</ctry><ctry>PT</ctry><ctry>RO</ctry><ctry>SE</ctry><ctry>SI</ctry><ctry>SK</ctry><ctry>TR</ctry></B840><B860><B861><dnum><anum>US2003021590</anum></dnum><date>20030711</date></B861><B862>en</B862></B860><B870><B871><dnum><pnum>WO2004008099</pnum></dnum><date>20040122</date><bnum>200404</bnum></B871></B870></B800></SDOBI>
</ep-patent-document>
