(19)
(11) EP 1 587 820 A2

(12)

(43) Date of publication:
26.10.2005 Bulletin 2005/43

(21) Application number: 03788252.9

(22) Date of filing: 07.08.2003
(51) International Patent Classification (IPC)7C07K 1/00
(86) International application number:
PCT/US2003/022496
(87) International publication number:
WO 2004/016642 (26.02.2004 Gazette 2004/09)
(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR
Designated Extension States:
AL LT LV MK

(30) Priority: 16.08.2002 US 404103 P

(71) Applicant: Pharmacia & Upjohn Company LLC
Kalamazoo, MI 49001 (US)

(72) Inventors:
  • STRATMAN, Nancy, C.
    Kalamazoo, MI 49006 (US)
  • CARTER, Donald, B.
    Kalamazoo, MI 49008 (US)

(74) Representative: Hirsch, Denise Marie et al
Pfizer European Pharma Patent Department 23-25, avenue du Docteur Lannelongue
75668 Paris Cedex 14
75668 Paris Cedex 14 (FR)

   


(54) ISOFORM SPECIFIC INTERACTIONS OF APOLIPOPROTEIN E TO AN INTERMEDIATE CONFORMATION OF ALZHEIMER A BETA PEPTIDE