(19)

(11)

EP 1 590 449 A2

(12)

(88) Date of publication A3: 16.09.2004 (43) Date of publication: 02.11.2005 Bulletin 2005/44 (21) Application number: 04706580.0 (22) Date of filing: 30.01.2004

(51) International Patent Classification (IPC)7: C12N 5/06, A61K 35/14 (86) International application number: PCT/BE2004/000017 (87) International publication number: WO 2004/067697 (12.08.2004 Gazette 2004/33)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR Designated Extension States: AL LT LV MK (30) Priority: 30.01.2003 GB 0302167 (71) Applicant: K.U.Leuven Research & Development 3000 Leuven (BE)	(72) Inventor: VAN GOOL, Stefaan B-3020 Herent (BE) (74) Representative: Bird, Ariane et al Bird Goen & Co, Klein Dalenstraat 42A 3020 Winksele 3020 Winksele (BE)