(19)

(11)

EP 1 590 450 A2

(12)

(43) Date of publication: 02.11.2005 Bulletin 2005/44 (21) Application number: 03799578.4 (22) Date of filing: 17.12.2003

(51) International Patent Classification (IPC)7: C12N 5/10, C07K 14/075, C12N 15/86, C12N 7/04 (86) International application number: PCT/EP2003/051034 (87) International publication number: WO 2004/056979 (08.07.2004 Gazette 2004/28)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR Designated Extension States: AL LT LV MK (30) Priority: 20.12.2002 EP 02102861 (71) Applicant: Crucell Holland B.V. 2333 CN Leiden (NL)	(72) Inventors: HAVENGA, Menzo, Jans, Emco NL-2401 KG Alphen aan den Rijn (NL) VOGELS, Ronald NL-3461 HW Linschoten (NL) MELLES, Sanne NL-2517 GE Den Haag (NL) (74) Representative: Klein, Bart et al Archimedesweg 4 2333 CN Leiden 2333 CN Leiden (NL)