(19)

(11)

EP 1 592 391 A2

(12)

(43) Date of publication: 09.11.2005 Bulletin 2005/45 (21) Application number: 04711255.2 (22) Date of filing: 13.02.2004

(51) International Patent Classification (IPC)7: A61K 6/00 (86) International application number: PCT/US2004/004445 (87) International publication number: WO 2004/071461 (26.08.2004 Gazette 2004/35)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR Designated Extension States: AL LT LV MK (30) Priority: 13.02.2003 US 366811 13.02.2003 US 447728 P (71) Applicant: UNIVERSITY OF ROCHESTER Rochester, NY 14642 (US)	(72) Inventor: CHANG, Chawnshang Pittsford, NY 14534 (US) (74) Representative: Lawrence, Malcolm Graham et al HLBBshaw Merlin House Falconry Court Baker's Lane Epping, Essex CM16 5DQ Epping, Essex CM16 5DQ (GB)