(19)

(11)

EP 1 592 424 A1

(12)

(43) Date of publication: 09.11.2005 Bulletin 2005/45 (21) Application number: 04703185.1 (22) Date of filing: 19.01.2004

(51) International Patent Classification (IPC)7: A61K 31/48, A61K 45/06, A61P 25/06 (86) International application number: PCT/EP2004/050024 (87) International publication number: WO 2004/069252 (19.08.2004 Gazette 2004/34)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR Designated Extension States: AL LT LV MK (30) Priority: 05.02.2003 EP 03100246 (71) Applicant: Pharmacia Italia S.p.A. 20152 Milano (IT)	(72) Inventors: BATTAGLIA, Angelo I-20146 Milan (IT) PAPINI, Maria, Grazia I-20132 Milan (IT) CARFAGNA, Nicola I-20014 Nerviano (IT) BARBANTI, Piero I-00137 Roma (IT) (74) Representative: Motion, Keith Robert et al Pfizer Limited, European Pharma Patent Department, Ramsgate Road Sandwich,Kent CT13 9NJ Sandwich,Kent CT13 9NJ (GB)