(19)

(11)

EP 1 592 707 A2

(12)

(88) Date of publication A3: 19.05.2005 (43) Date of publication: 09.11.2005 Bulletin 2005/45 (21) Application number: 04710953.3 (22) Date of filing: 13.02.2004

(51) International Patent Classification (IPC)7: C07K 14/47 (86) International application number: PCT/IB2004/000986 (87) International publication number: WO 2004/072094 (26.08.2004 Gazette 2004/35)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR Designated Extension States: AL LT LV MK (30) Priority: 14.02.2003 US 447316 P (71) Applicants: FONDAZIONE CENTRO SAN RAFFAELE DEL MONTE TABOR 20132 Milano (IT) Fondazione Telethon 00161 Roma (IT)	(72) Inventors: BIANCHI, Marco, E.,San Raffaele Scientific Inst. I-20132 Milano (IT) MUSCO, Giovanna A.,San Raffaele Scientific Inst. I-20132 Milan (IT) (74) Representative: Iannone, Carlo Luigi et al Ing. Barzanò & Zanardo Roma S.p.A. Via Piemonte, 26 00187 Roma 00187 Roma (IT)