(19)

(11)

EP 1 592 811 A2

(12)

(88) Date of publication A3: 03.03.2005 (43) Date of publication: 09.11.2005 Bulletin 2005/45 (21) Application number: 04710266.0 (22) Date of filing: 11.02.2004

(51) International Patent Classification (IPC)7: C12Q 1/68, C07K 16/18, G01N 33/53 (86) International application number: PCT/US2004/004118 (87) International publication number: WO 2004/072265 (26.08.2004 Gazette 2004/35)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR Designated Extension States: AL LT LV MK (30) Priority: 11.02.2003 US 446133 P 03.04.2003 US 459782 P 23.01.2004 US 538246 P (71) Applicant: Wyeth Madison, New Jersey 07940-0874 (US)	(72) Inventors: BURCZYNSKI, Michael Swampscott, MA 01907 (US) TWINE, Natalie Goffstown, NH 03045 (US) DORNER, Andrew, J. Lexington, MA 02421 (US) TREPICCHIO, William, L. Andover, MA 01810 (US) (74) Representative: Denholm, Anna Marie et al Wyeth Pharmaceuticals, Huntercombe Lane South Taplow, MaidenheadBerkshire SL6 0PH Taplow, MaidenheadBerkshire SL6 0PH (GB)