(19)
(11) EP 1 593 959 A3

(12) EUROPEAN PATENT APPLICATION

(88) Date of publication A3:
05.07.2006 Bulletin 2006/27

(43) Date of publication A2:
09.11.2005 Bulletin 2005/45

(21) Application number: 05015729.6

(22) Date of filing: 11.01.2000
(51) International Patent Classification (IPC): 
G01N 27/26(2006.01)
C12Q 1/00(2006.01)
G01N 27/30(2006.01)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

(30) Priority: 12.01.1999 US 228855

(62) Application number of the earlier application in accordance with Art. 76 EPC:
00906895.8 / 1155310

(71) Applicant: Diabetes Diagnostics, Inc.
Waltham, MA 02453 (US)

(72) Inventors:
  • Mcaleer, Jerome F.
    Wantage OX12 ONR (GB)
  • Scott, David
    Witney Oxon, OX8 6S2 (GB)
  • Plotkin, Elliot V.
    Inverness IV2 3 JZ (GB)
  • Hall, Geoff
    Ross-shire IV10 8SH (GB)
  • Alvarez-Icaza, Manuel
    Inverness IV* 3AJ (GB)

(74) Representative: Samuels, Adrian James 
Frank B. Dehn & Co. St Bride's House 10 Salisbury Square
London EC4Y 8JD
London EC4Y 8JD (GB)

   


(54) Disposable test strips with integrated reagent/blood separation layer


(57) An improved disposable glucose test strip for use in a test meter of the type which receives a disposable test strip and a sample of blood from a patient and performs an electrochemical analysis is made using a non-conductive integrated reagent/blood separation layer containing a filler, an enzyme effective to oxidize glucose, e.g. glucose oxidase, and a mediator effective to transfer electrons from the enzyme. The integrated layer formulation is printed over a conductive carbon element to form a working electrode. The filler, for example a silica filler, is selected to have a balance of hydrophobicity such that one drying it forms a two-dimensional network on the surface of the conductive element. The response of this test strip is essentially temperature independent over relevant temperature ranges and is substantially insensitive to the hematocrit of the patient.










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