(19)
(11) EP 1 594 433 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
21.12.2016 Bulletin 2016/51

(45) Mention of the grant of the patent:
13.01.2016 Bulletin 2016/02

(21) Application number: 04702173.8

(22) Date of filing: 14.01.2004
(51) International Patent Classification (IPC): 
A61K 38/39(2006.01)
A61K 45/06(2006.01)
A61P 35/00(2006.01)
A61K 31/4745(2006.01)
A61K 33/24(2006.01)
A61K 31/00(2006.01)
A61K 38/17(2006.01)
A61K 31/513(2006.01)
A61K 31/7048(2006.01)
(86) International application number:
PCT/US2004/000901
(87) International publication number:
WO 2004/064785 (05.08.2004 Gazette 2004/32)

(54)

CANCER THERAPY SENSITIZER

SENSIBILISATOR FÜR KREBSTHERAPIE

SENSIBILISANT D'UNE THERAPIE DE CANCER


(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR

(30) Priority: 14.01.2003 US 440009 P

(43) Date of publication of application:
16.11.2005 Bulletin 2005/46

(60) Divisional application:
12183770.2 / 2561887

(73) Proprietor: Dana-Farber Cancer Institute, Inc.
Boston, MA 02115-5450 (US)

(72) Inventors:
  • TAI, Isabelle, T.
    Vancouver, B.C. V6Z 3A9 (CA)
  • CHEN, Lan, Bo
    Lexington, MA 02420 (US)

(74) Representative: D Young & Co LLP 
120 Holborn
London EC1N 2DY
London EC1N 2DY (GB)


(56) References cited: : 
WO-A-02/089772
US-B1- 6 406 693
US-A1- 2003 082 228
US-B1- 6 475 784
   
  • G.K. YIU ET AL: "SPARC (Secreted Protein Acidic and Rich in Cysteine) Induces Apoptosis in Ovarian Cancer Cells" AMERICAN JOURNAL OF PATHOLOGY, vol. 159, no. 2, February 2001 (2001-02), pages 609-622, XP002983766
  • I.A. CREE ET AL: "Chemosensitization of Solid Tumor Cells by Alteration of their Susceptibility to Apoptosis" CURRENT OPINION IN INVESTIGATIONAL DRUGS, vol. 3, no. 4, April 2002 (2002-04), pages 641-647, XP008095641
  • N. DHANESUAN ET AL: "Doxycycline-inducible expression of SPARC/Osteonectin/BM40 in MDA-MB-231 human breast cancer cells results in growth inhibition." BREAST CANCER RESEARCH, vol. 75, no. 1, September 2002 (2002-09), pages 73-85, XP002493062
  • U. STEIN ET AL: "Reversal of Multidrug Resistance by Transduction of Cytokine Genes into Human Colon Carcinoma Cells" JOURNAL OF THE NATIONAL CANCER INSTITUTE, vol. 88, no. 19, 2 October 1996 (1996-10-02), pages 1383-1392, XP002493063
  • YIU G.K. ET AL: 'SPARC (Secreted Protein Acidic and Rich in Cysteine) Induces Apoptosis in Ovarian Cancer Cells' AM J PATHOL vol. 159, no. 2, August 2001, pages 609 - 662, XP002983766
  • CHLENSKI A. ET AL: 'SPARC Is a Key Schwannian-derived Inhibitor Controlling Neuroblastoma Tumor Angiogenesis' CANCER RES vol. 62, 15 December 2002, pages 7357 - 7363, XP002986916
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).