<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE ep-patent-document PUBLIC "-//EPO//EP PATENT DOCUMENT 1.5//EN" "ep-patent-document-v1-5.dtd">
<ep-patent-document id="EP04702173B8W1" file="EP04702173W1B8.xml" lang="en" country="EP" doc-number="1594433" kind="B8" correction-code="W1" date-publ="20161221" status="c" dtd-version="ep-patent-document-v1-5">
<SDOBI lang="en"><B000><eptags><B001EP>ATBECHDEDKESFRGBGRITLILUNLSEMCPTIESI....FIRO..CY..TRBGCZEEHU..SK....................................</B001EP><B003EP>*</B003EP><B005EP>J</B005EP><B007EP>JDIM360 Ver 1.28 (29 Oct 2014) -  2999001/0</B007EP><B078EP><date>20161014</date></B078EP></eptags></B000><B100><B110>1594433</B110><B120><B121>CORRECTED EUROPEAN PATENT SPECIFICATION</B121></B120><B130>B8</B130><B132EP>B1</B132EP><B140><date>20161221</date></B140><B150><B151>W1</B151><B153>73</B153><B155><B1551>de</B1551><B1552>Bibliographie</B1552><B1551>en</B1551><B1552>Bibliography</B1552><B1551>fr</B1551><B1552>Bibliographie</B1552></B155></B150><B190>EP</B190></B100><B200><B210>04702173.8</B210><B220><date>20040114</date></B220><B240><B241><date>20050805</date></B241><B242><date>20100910</date></B242></B240><B250>en</B250><B251EP>en</B251EP><B260>en</B260></B200><B300><B310>440009 P</B310><B320><date>20030114</date></B320><B330><ctry>US</ctry></B330></B300><B400><B405><date>20161221</date><bnum>201651</bnum></B405><B430><date>20051116</date><bnum>200546</bnum></B430><B450><date>20160113</date><bnum>201602</bnum></B450><B452EP><date>20150720</date></B452EP><B472><B475><date>20160131</date><ctry>BE</ctry><date>20160113</date><ctry>NL</ctry><date>20160414</date><ctry>GR</ctry><date>20160113</date><ctry>FI</ctry><date>20160113</date><ctry>AT</ctry><date>20160513</date><ctry>PT</ctry><date>20160113</date><ctry>SE</ctry><date>20160131</date><ctry>CH</ctry><date>20160131</date><ctry>LI</ctry><date>20160113</date><ctry>DK</ctry><date>20160113</date><ctry>MC</ctry><date>20160113</date><ctry>EE</ctry><date>20160113</date><ctry>SK</ctry><date>20160113</date><ctry>RO</ctry><date>20160113</date><ctry>CZ</ctry></B475></B472><B480><date>20161221</date><bnum>201651</bnum></B480></B400><B500><B510EP><classification-ipcr sequence="1"><text>A61K  38/39        20060101AFI20150527BHEP        </text></classification-ipcr><classification-ipcr sequence="2"><text>A61K  31/00        20060101ALI20150527BHEP        </text></classification-ipcr><classification-ipcr sequence="3"><text>A61K  45/06        20060101ALI20150527BHEP        </text></classification-ipcr><classification-ipcr sequence="4"><text>A61K  38/17        20060101ALI20150527BHEP        </text></classification-ipcr><classification-ipcr sequence="5"><text>A61P  35/00        20060101ALI20150527BHEP        </text></classification-ipcr><classification-ipcr sequence="6"><text>A61K  31/513       20060101ALI20150527BHEP        </text></classification-ipcr><classification-ipcr sequence="7"><text>A61K  31/4745      20060101ALI20150527BHEP        </text></classification-ipcr><classification-ipcr sequence="8"><text>A61K  31/7048      20060101ALI20150527BHEP        </text></classification-ipcr><classification-ipcr sequence="9"><text>A61K  33/24        20060101ALI20150527BHEP        </text></classification-ipcr></B510EP><B540><B541>de</B541><B542>SENSIBILISATOR FÜR KREBSTHERAPIE</B542><B541>en</B541><B542>CANCER THERAPY SENSITIZER</B542><B541>fr</B541><B542>SENSIBILISANT D'UNE THERAPIE DE CANCER</B542></B540><B560><B561><text>WO-A-02/089772</text></B561><B561><text>US-A1- 2003 082 228</text></B561><B561><text>US-B1- 6 406 693</text></B561><B561><text>US-B1- 6 475 784</text></B561><B562><text>G.K. YIU ET AL: "SPARC (Secreted Protein Acidic and Rich in Cysteine) Induces Apoptosis in Ovarian Cancer Cells" AMERICAN JOURNAL OF PATHOLOGY, vol. 159, no. 2, February 2001 (2001-02), pages 609-622, XP002983766</text></B562><B562><text>I.A. CREE ET AL: "Chemosensitization of Solid Tumor Cells by Alteration of their Susceptibility to Apoptosis" CURRENT OPINION IN INVESTIGATIONAL DRUGS, vol. 3, no. 4, April 2002 (2002-04), pages 641-647, XP008095641</text></B562><B562><text>N. DHANESUAN ET AL: "Doxycycline-inducible expression of SPARC/Osteonectin/BM40 in MDA-MB-231 human breast cancer cells results in growth inhibition." BREAST CANCER RESEARCH, vol. 75, no. 1, September 2002 (2002-09), pages 73-85, XP002493062</text></B562><B562><text>U. STEIN ET AL: "Reversal of Multidrug Resistance by Transduction of Cytokine Genes into Human Colon Carcinoma Cells" JOURNAL OF THE NATIONAL CANCER INSTITUTE, vol. 88, no. 19, 2 October 1996 (1996-10-02), pages 1383-1392, XP002493063</text></B562><B562><text>YIU G.K. ET AL: 'SPARC (Secreted Protein Acidic and Rich in Cysteine) Induces Apoptosis in Ovarian Cancer Cells' AM J PATHOL vol. 159, no. 2, August 2001, pages 609 - 662, XP002983766</text></B562><B562><text>CHLENSKI A. ET AL: 'SPARC Is a Key Schwannian-derived Inhibitor Controlling Neuroblastoma Tumor Angiogenesis' CANCER RES vol. 62, 15 December 2002, pages 7357 - 7363, XP002986916</text></B562><B565EP><date>20080902</date></B565EP></B560></B500><B600><B620EP><parent><cdoc><dnum><anum>12183770.2</anum><pnum>2561887</pnum></dnum><date>20120910</date></cdoc></parent></B620EP></B600><B700><B720><B721><snm>TAI, Isabelle, T.</snm><adr><str>2502-1408 Strathmore Mews N.</str><city>Vancouver, B.C. V6Z 3A9</city><ctry>CA</ctry></adr></B721><B721><snm>CHEN, Lan, Bo</snm><adr><str>184 E. Emerson Road</str><city>Lexington, MA 02420</city><ctry>US</ctry></adr></B721></B720><B730><B731><snm>Dana-Farber Cancer Institute, Inc.</snm><iid>101238798</iid><irf>P023631EP RCD</irf><adr><str>450 Brookline Avenue</str><city>Boston, MA 02115-5450</city><ctry>US</ctry></adr></B731></B730><B740><B741><snm>D Young &amp; Co LLP</snm><iid>101533551</iid><adr><str>120 Holborn</str><city>London EC1N 2DY</city><ctry>GB</ctry></adr></B741></B740></B700><B800><B840><ctry>AT</ctry><ctry>BE</ctry><ctry>BG</ctry><ctry>CH</ctry><ctry>CY</ctry><ctry>CZ</ctry><ctry>DE</ctry><ctry>DK</ctry><ctry>EE</ctry><ctry>ES</ctry><ctry>FI</ctry><ctry>FR</ctry><ctry>GB</ctry><ctry>GR</ctry><ctry>HU</ctry><ctry>IE</ctry><ctry>IT</ctry><ctry>LI</ctry><ctry>LU</ctry><ctry>MC</ctry><ctry>NL</ctry><ctry>PT</ctry><ctry>RO</ctry><ctry>SE</ctry><ctry>SI</ctry><ctry>SK</ctry><ctry>TR</ctry></B840><B860><B861><dnum><anum>US2004000901</anum></dnum><date>20040114</date></B861><B862>en</B862></B860><B870><B871><dnum><pnum>WO2004064785</pnum></dnum><date>20040805</date><bnum>200432</bnum></B871></B870></B800></SDOBI>
</ep-patent-document>
