(19)
(11) EP 1 594 990 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
24.02.2016 Bulletin 2016/08

(45) Mention of the grant of the patent:
02.12.2015 Bulletin 2015/49

(21) Application number: 04713499.4

(22) Date of filing: 23.02.2004
(51) International Patent Classification (IPC): 
C12Q 1/68(2006.01)
(86) International application number:
PCT/CA2004/000241
(87) International publication number:
WO 2004/074500 (02.09.2004 Gazette 2004/36)

(54)

METHOD OF MONITORING GENOMIC INSTABILITY USING 3D MICROSCOPY AND ANALYSIS

VERFAHREN ZUR GENOMISCHEN-INSTABILITÄTS-BESTIMUNG DURCH VERWENDUNG VON 3D-MIKROSKOPIE UND ANALYSE

PROCEDE POUR SURVEILLER L'INSTABILITE GENOMIQUE PAR MICROSCOPIE ET ANALYSE TRIDIMENSIONNELLES

(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR

(30) Priority: 21.02.2003 US 448545 P

(43) Date of publication of application:
16.11.2005 Bulletin 2005/46

(73) Proprietor: 3D Signatures Inc.
Winnipeg, MB R3C 3R8 (CA)

(72) Inventors:
  • MAI, Sabine
    Winnipeg, Manitoba R3N 1M9 (CA)
  • CHUANG, Tony, Chih, Yuan
    Winnipeg, Manitoba R3L 0E9 (CA)
  • MOSHIR, Sharareh
    69214 Eppelheim (DE)
  • GARINI, Yuval
    NL-2275 VC Voorburg (NL)
  • VERMOLEN, Bartholomeus J.
    3544 DL Utrecht (NL)

(74) Representative: Mai, Dörr, Besier 
Patentanwälte Steuerberater/Wirtschaftsprüfer Kreuzberger Ring 64
65205 Wiesbaden
65205 Wiesbaden (DE)


(56) References cited: : 
US-B1- 6 506 563
   
  • MAIERHOFER CHRISTINE ET AL: "Multicolor deconvolution microscopy of thick biological specimens." AMERICAN JOURNAL OF PATHOLOGY. FEB 2003, vol. 162, no. 2, 1 February 2003 (2003-02-01), pages 373-379, XP002291317 ISSN: 0002-9440
  • SCHAEFER L H ET AL: "Generalized approach for accelerated maximum likelihood based image restoration applied to three-dimensional fluorescence microscopy." JOURNAL OF MICROSCOPY. NOV 2001, vol. 204, no. Pt 2, November 2001 (2001-11), pages 99-107, XP002291318 ISSN: 0022-2720
  • HENDERSON S ET AL: "IN SITU ANALYSIS OF CHANGES IN TELOMERE SIZE DURING REPLICATIVE AGING AND CELL TRANSFORMATION" THE JOURNAL OF CELL BIOLOGY, ROCKEFELLER UNIVERSITY PRESS, US, vol. 134, no. 1, July 1996 (1996-07), pages 1-12, XP000978722 ISSN: 0021-9525
  • BASS HANK W ET AL: "Telomeres cluster de novo before the initiation of synapsis: A three-dimensional spatial analysis of telomere positions before and during meiotic prophase" JOURNAL OF CELL BIOLOGY, vol. 137, no. 1, 1997, pages 5-18, XP002293703 ISSN: 0021-9525
  • WEIERICH CLAUDIA ET AL: "Three-dimensional arrangements of centromeres and telomeres in nuclei of human and murine lymphocytes." CHROMOSOME RESEARCH, vol. 11, no. 5, 2003, pages 485-502, XP009035114 ISSN: 0967-3849
  • CHUANG TONY CHIH YUAN ET AL.: "The three-dimensional organization of telomeres in the nucleus of mammalian cells" BMC BIOLOGY, vol. 2, 3 June 2004 (2004-06-03), XP002293702 Retrieved from the Internet: URL:http://www.biomedcentral.com/1741-7007 /2/12>
  • C. R. COWAN: 'The Polar Arrangement of Telomeres in Interphase and Meiosis. Rabl Organization and the Bouquet' PLANT PHYSIOLOGY vol. 125, no. 2, 01 February 2001, pages 532 - 538, XP055020969 DOI: 10.1104/pp.125.2.532 ISSN: 0032-0889
   
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