(19)

(11)

EP 1 596 928 A2

(12)

(43) Date of publication: 23.11.2005 Bulletin 2005/47 (21) Application number: 04714079.3 (22) Date of filing: 24.02.2004

(51) International Patent Classification (IPC)7: A61N 1/00 (86) International application number: PCT/US2004/005057 (87) International publication number: WO 2004/075974 (10.09.2004 Gazette 2004/37)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR Designated Extension States: AL LT LV MK (30) Priority: 25.02.2003 US 450534 P 05.03.2003 US 452361 P 30.04.2003 US 466890 P 30.04.2003 US 466805 P 19.06.2003 US 479933 P 20.08.2003 US 496437 P (71) Applicant: Leptos Biomedical, Inc. La Jolla, CA 92037 (US)	(72) Inventor: DOBAK, John, D., III La Jolla, CA 92037 (US) (74) Representative: Kazi, Ilya et al Mathys & Squire 120 Holborn London EC1N 2SQ London EC1N 2SQ (GB)