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(11)

EP 1 597 378 A2

(12)

(88) Date of publication A3: 23.12.2004 (43) Date of publication: 23.11.2005 Bulletin 2005/47 (21) Application number: 03808563.5 (22) Date of filing: 24.12.2003

(51) International Patent Classification (IPC)7: C12P 21/00, A01K 67/027, A01K 67/033, C07H 21/04, C12N 15/00 (86) International application number: PCT/US2003/041261 (87) International publication number: WO 2004/067706 (12.08.2004 Gazette 2004/33)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR Designated Extension States: AL LT LV MK (30) Priority: 21.01.2003 US 441377 P 21.01.2003 US 441381 P 21.01.2003 US 441392 P 21.01.2003 US 441405 P 21.01.2003 US 441447 P 21.01.2003 US 441502 P 26.06.2003 US 609019 (71) Applicants: Transgenrx, Inc. Dallas, TX 75234 (US) THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE Baton Rouge, LA 70894-5055 (US)

(72) Inventors: COOPER, Richard, K. Baton Rouge, LA 70810 (US) FIORETTI, William, C. Grapevine, TX 76051 (US) CADD, Gary, G. Grapevine, TX 76051 (US) (74) Representative: Dey, Michael et al Weickmann & Weickmann, Postfach 860 820 81635 München 81635 München (DE)