(19)

(11)

EP 1 599 494 A2

(12)

(43) Date of publication: 30.11.2005 Bulletin 2005/48 (21) Application number: 04705679.1 (22) Date of filing: 27.01.2004

(51) International Patent Classification (IPC)7: C07K 1/00 (86) International application number: PCT/US2004/002290 (87) International publication number: WO 2004/069859 (19.08.2004 Gazette 2004/34)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR Designated Extension States: AL LT LV MK (30) Priority: 29.01.2003 US 443691 P (71) Applicant: Oregon Health and Science University Portland, Oregon 97201 (US)	(72) Inventor: CONN, P., Michael Beaverton, Oregon 97006-3448 (US) (74) Representative: Gowshall, Jonathan Vallance  Forrester & Boehmert Pettenkoferstrasse 20-22 80336 München 80336 München (DE)