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EP 1 603 879 A2

(12)

(88) Date of publication A3: 23.12.2004 (43) Date of publication: 14.12.2005 Bulletin 2005/50 (21) Application number: 04716142.7 (22) Date of filing: 01.03.2004

(51) International Patent Classification (IPC)7: C07D 213/81, C07D 405/14, C07D 417/14, C07D 405/12, C07D 413/14, A61K 31/4412, C07D 401/12, C07D 401/04, A61K 31/4433, C07D 213/83, C07D 413/04, C07D 213/86, C07D 417/02 (86) International application number: PCT/US2004/006295 (87) International publication number: WO 2004/078128 (16.09.2004 Gazette 2004/38)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR Designated Extension States: AL LT LV MK (30) Priority: 28.02.2003 US 450324 P (71) Applicant: Bayer Pharmaceuticals Corporation West Haven, CT 06516-4175 (US)

(72) Inventors: DUMAS, Jacques Bethany, CT 06524 (US) LEE, Wendy Hamden, CT 06518 (US) CHEN, Yuanwei North Haven, CT 06473 (US) ADNANE, Lila Madison, CT 06443 (US) SCOTT, William, J. Guilford, CT 06437 (US) VERMA, Sharad New Haven, CT 06519 (US) CHEN, Jianging New Haven, CT 06515 (US) CHEN, Zhi Hamden, CT 06514 (US) YI, Lin Milford, CT 06460 (US) (74) Representative: Ziebig, Marlene et al Anwaltskanzlei Gulde Hengelhaupt Ziebig & Schneider Wallstrasse 58/59 10179 Berlin 10179 Berlin (DE)