ATBECHDEDKESFRGBGRITLILUNLSEMCPTIESILTLVFIROMKCYALTRBGCZEEHUPLSK..HR............JDIM360 (Ver 1.5 21 Nov 2005) - 1990850/0 1999001/01604662CORRECTED EUROPEAN PATENT APPLICATIONA8A120060412W10000000072deBibliographieenBibliographyfrBibliographieEP04013510.520040608enenen200604122006152005121420055020060412200615A61K 31/401 20000101AFI20041115BHEP A61K 31/40 19850101ALI20041115BHEP A61K 31/472 20000101ALI20041115BHEP A61K 31/495 19850101ALI20041115BHEP C07D 207/16 19850101ALI20041115BHEP C07D 207/09 19850101ALI20041115BHEP C07D 207/08 19850101ALI20041115BHEP C07D 217/26 19850101ALI20041115BHEP C07D 217/14 19850101ALI20041115BHEP C07D 217/16 19850101ALI20041115BHEP C07D 241/04 19850101ALI20041115BHEP A61P 3/10 20000101ALI20041115BHEP de1-¬(3R)-Amino-4-(2-fluoro-phenyl)-butyl|-pyrrolidin-(2R)-carbonsäure-benzylamine-Derivate und verwandte Verbindungen als Dipeptidyl-Peptidase IV (DPP-IV) Inhibitoren zur Behandlung von Typ 2 Diabetes Mellitusen1-¬(3R)-Amino-4-(2-fluoro-phenyl)-butyl|-pyrrolidine-(2R)-carboxylic acid benzyl amine derivatives and related compounds as dipeptidyl peptidase IV (DPP-IV) inhibitors for the treatment of type 2 diabetes mellitusfrDerivés de la benzyl amine du acide carboxylique (2R) de la 1-¬(3R)-Amino-4-(2-fluoro-phenyl)-butyl|-pyrrolidine et composés similaires pour l'utilisation comme inhibiteurs de la peptidase dipeptidyl IV (DPP-IV) pour le traitement de la diabetes mellitus de type 2Santhera Pharmaceuticals (Deutschland) Aktiengesellschaft07101850EP33189KGstoIm Neuenheimer Feld 518-51969120 HeidelbergDEEdwards, Paul JohnKleinschmidtstr. 1769115 HeidelbergDECerezo-Galvez, SilviaFischerstr. 2942287 WuppertalDEFeurer, AchimErlenbrunnenweg 569259 WilhelmsfeldDEMatassa, Victor GiulioIm Brambusch 2069493 HirschbergDENordhoff, SonjaRuhweg 469198 SchrisheimDEHill, OliverGartenstr. 1369239 NeckarsteinachDEThiemann, MeinolfHans-Thoma-Platz 2469121 HeidelbergDELopez-Canet, MeritxellWundstr. 9, App. 1869123 HeidelbergDEGoldbach, Klaraet al00059031Grünecker, Kinkeldey, Stockmair & Schwanhäusser Anwaltssozietät Maximilianstrasse 5880538 MünchenDEATBEBGCHCYCZDEDKEEESFIFRGBGRHUIEITLILUMCNLPLPTROSESISKTRALHRLTLVMK

The invention relates to compounds of formula (I) wherein R1-9, Z, n, X, A, and Rb have the meaning as cited in the description and the claims. Said compounds are useful as DPP-IV inhibitors. The invention also relates to the preparation of such compounds as well as the production and use thereof as medicament for the treatment of type 2 diabetes mellitus, obesity and lipid disorders.