(19)
(11) EP 1 604 676 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
14.12.2016 Bulletin 2016/50

(45) Mention of the grant of the patent:
02.11.2016 Bulletin 2016/44

(21) Application number: 05012130.0

(22) Date of filing: 06.06.2005
(51) International Patent Classification (IPC): 
C12N 9/02(2006.01)

(54)

Aromatase transcription activators extracts

Aromatase Transkriptionsaktivatorenextrakte

Extraits comprenant des activateurs de transcription de l'aromatase


(84) Designated Contracting States:
DE FR GB

(30) Priority: 07.06.2004 JP 2004168996
07.06.2004 JP 2004169052

(43) Date of publication of application:
14.12.2005 Bulletin 2005/50

(73) Proprietor: KAO CORPORATION
Tokyo 103-8210 (JP)

(72) Inventors:
  • Kakuo, Shingo, c/o Kao Corporation
    Ichikaimachi, Haga-gun, Tochigi 321-3497 (JP)
  • Moriwaki, Shigeru, c/o Kao Corporation
    Ichikaimachi, Haga-gun, Tochigi 321-3497 (JP)
  • Ohuchi, Atsushi, c/o Kao Corporation
    Ichikaimachi, Haga-gun, Tochigi 321-3497 (JP)
  • Kusuoku, Hiroshi, c/o Kao Corporation
    Ichikaimachi, Haga-gun, Tochigi 321-3497 (JP)

(74) Representative: Hoffmann Eitle 
Patent- und Rechtsanwälte PartmbB Arabellastraße 30
81925 München
81925 München (DE)


(56) References cited: : 
EP-A- 1 338 283
US-A1- 2004 265 399
WO-A-00/13661
   
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  • TAKEUCHI T ET AL: "Effect of traditional herbal medicine, shakuyaku-kanzo-to on total and free serum testosterone levels." THE AMERICAN JOURNAL OF CHINESE MEDICINE. 1989, vol. 17, no. 1-2, 1989, pages 35-44, XP008051240 ISSN: 0192-415X
  • OTA H ET AL: "[Stimulatory action of shakuyaku on aromatase activity in cultured rat follicles]" NIPPON SANKA FUJINKA GAKKAI ZASSHI. MAY 1989, vol. 41, no. 5, May 1989 (1989-05), pages 525-529, XP008051238 ISSN: 0300-9165
  • TAKAHASHI K ET AL: "Effect of TJ-68 (shakuyaku-kanzo-to) on polycystic ovarian disease." INTERNATIONAL JOURNAL OF FERTILITY AND MENOPAUSAL STUDIES. 1994 MAR-APR, vol. 39, no. 2, March 1994 (1994-03), pages 69-76, XP008051237 ISSN: 1069-3130
  • DATABASE BIOSIS [Online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1982, BELLINO F L ET AL: "ESTROGEN SYNTHETASE STIMULATION BY DI BUTYRYL CYCLIC AMP IN HUMAN CHORIO CARCINOMA CELL CULTURE THE RELATIVE BIOSYNTHETIC RATE OF THE NADP REDUCED FORM CYTOCHROME C REDUCTASE COMPONENT" XP002342115 Database accession no. PREV198375073483 & ENDOCRINOLOGY, vol. 111, no. 4, 1982, pages 1038-1044, ISSN: 0013-7227
  • BAIL LE J-C ET AL: "Chalcones are potent inhibitors of aromatase and 17.beta.-hydroxysteroid dehydrogenase activities" LIFE SCIENCES, PERGAMON PRESS, OXFORD, GB, vol. 68, 2001, pages 751-761, XP002241304 ISSN: 0024-3205
  • YEH-CHIH KAO ET AL: "MOLECULAR BASIS OF THE INHIBITION OF HUMAN AROMATASE (ESTROGEN SYNTHETASE) BY FLAVONE AND ISOFLAVONE PHYTOESTROGENS: A SITE-DIRECTED MUTAGENESIS STUDY" ENVIRONMENTAL HEALTH PERSPECTIVES, vol. 106, no. 2, February 1998 (1998-02), pages 85-92, XP000981752 ISSN: 0091-6765
  • GUTHRIE N ET AL: "EFFECTIVENESS OF CITRUS FLAVONOIDS ON HUMAN PROSTATE, COLON, LUNG, AND MELANOMA CANCER-CELL PROLIFERATION" AMERICAN CHEMICAL SOCIETY. ABSTRACTS OF PAPER. AT THE NATIONAL MEETING, AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC, US, vol. 219, no. 1/2, 26 March 2000 (2000-03-26), page AFGD183, XP008016727 ISSN: 0065-7727
   
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