(19)

(11)

EP 1 608 323 A2

(12)

(88) Date of publication A3: 10.02.2005 (43) Date of publication: 28.12.2005 Bulletin 2005/52 (21) Application number: 04758499.0 (22) Date of filing: 26.03.2004

(51) International Patent Classification (IPC)7: A61K 7/043 (86) International application number: PCT/US2004/009502 (87) International publication number: WO 2004/087080 (14.10.2004 Gazette 2004/42)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR Designated Extension States: AL LT LV MK (30) Priority: 28.03.2003 US 401470 28.03.2003 US 402118 28.03.2003 US 402693 (71) Applicant: NEUTROGENA CORPORATION Los AngelesCalifornia 90045-5544 (US)	(72) Inventors: COLLINS, Carol Granada Hill, CA 91344 (US) BEALER, Lewis Santa Monica, CA 90404 (US) APPA, Yohini Torrance, CA 90501 (US) HORNBY, Sidney San Pedro, CA 90732 (US) (74) Representative: Fisher, Adrian John et al CARPMAELS & RANSFORD 43-45 Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)